LOT Winter School 2019

The Neurolinguistics of Syntax: Investigations of sentence processing in healthy and aphasic speakers

Dirk-Bart den Ouden


Discovery I Building, Office 202 C

915 Greene Street, Columbia, SC 29208

Email address: denouden@sc.edu

Website teacher: https://www.sc.edu/study/colleges_schools/public_h...

Title of the course: The Neurolinguistics of Syntax: Investigations of sentence processing in healthy and aphasic speakers.

Teacher: Dirk-Bart den Ouden

Course info
Intermediate to Advanced

Course description:

In this course, we will discuss past and current investigations into how the brain supports the processing of syntax for production and comprehension. After setting the stage by reviewing the history of such investigations and their theoretical bases in the past century, we will focus on neuroimaging studies in healthy speakers and clinical populations, as well as on voxel-based and connectome-based lesion-symptom mapping studies in stroke survivors. These lectures will also address the methods themselves. We will end with a review of recent neurolinguistic models of syntactic processing, come up with new questions to ask, and discuss ways in which we may address these questions.

Day-to-day program

Monday: The neurolinguistics of syntax, a historical perspective.

Tuesday: Functional neuroimaging of syntactic processing in unimpaired speakers

Wednesday: Functional neuroimaging of syntactic processing in speakers with aphasia

Thursday: Lesion-symptom mapping of syntax in speakers with aphasia

Friday: Recent models of syntax in the brain

Reading list

All readings will be provided to students before the course

Course readings (prioritized):

Lecture 1:

  1. Goodglass, H. (1993). Chapter 6, Disorders of Syntax and Morphology. In: H. Goodglass, Understanding Aphasia. San Diego: Academic Press, Inc., pp 101-121.
  2. Grodzinsky, Y. (2000). The neurology of syntax: language use without Broca's area. Behav Brain Sci, 23(1), 1-21.
  3. Dick, F., Bates, E., Wulfeck, B., Utman, J. A., Dronkers, N., & Gernsbacher, M. A. (2001). Language deficits, localization, and grammar: Evidence for a distributive model of language breakdown in aphasic patients and neurologically intact individuals. Psychological Review, 108(4), 759-788.

Lecture 2:

  1. Grodzinsky, Y., & Friederici, A. D. (2006). Neuroimaging of syntax and syntactic processing. Current Opinion in Neurobiology, 16, 240-246.
  2. Den Ouden, D.-B., Saur, D., Mader, W., Schelter, B., Lukic, S., Wali, E., . . . Thompson, C. K. (2012). Network modulation during complex syntactic processing. Neuroimage, 59(1), 815-823.
  3. Rogalsky, C., Almeida, D., Sprouse, J., & Hickok, G. (2015). Sentence processing selectivity in Broca's area: evidence for structure but not syntactic movement. Language, Cognition and Neuroscience, 30(10), 1326-1338.

Lecture 3:

  1. Thompson, C. K., Den Ouden, D.-B., Bonakdarpour, B., Garibaldi, K., & Parrish, T. B. (2010). Neural plasticity and treatment-induced recovery of sentence processing in agrammatism. Neuropsychologia, 48(11), 3211-3227.
  2. Tyler, L. K., Marslen-Wilson, W. D., Randall, B., Wright, P., Devereux, B. J., Zhuang, J., . . . Stamatakis, E. A. (2011). Left inferior frontal cortex and syntax: function, structure and behaviour in patients with left hemisphere damage. Brain, 134(Pt 2), 415-431.
  3. Schonberger, E., Heim, S., Meffert, E., Pieperhoff, P., da Costa Avelar, P., Huber, W., . . . Grande, M. (2014). The neural correlates of agrammatism: Evidence from aphasic and healthy speakers performing an overt picture description task. Front Psychol, 5, 246.

Lecture 4:

  1. Den Ouden, D.B., Malyutina, S., Basilakos, A., Bonilha, L., Gleichgerrcht, E., Rorden, C., Yourganov, G., Hillis, A.E., Hickok, G. & Fridriksson, J., (submitted), Cortical and structural connectivity damage correlated with impaired syntactic processing.
  2. Rogalsky, C., LaCroix, A. N., Chen, K. H., Anderson, S. W., Damasio, H., Love, T., & Hickok, G. (2018). The Neurobiology of Agrammatic Sentence Comprehension: A Lesion Study. J Cogn Neurosci, 30(2), 234-255.
  3. Caplan, D., Michaud, J., Hufford, R., & Makris, N. (2016). Deficit-Lesion Correlations in Syntactic Comprehension in Aphasia. Brain and Language, 152, 14-27.

Lecture 5:

  1. Matchin, W. & Hickok, G. (manuscript) The cortical organization of syntax.
  2. Friederici, A. D. (2012). The cortical language circuit: from auditory perception to sentence comprehension. Trends in Cognitive Sciences, 16(5), 262-268.
  3. Bornkessel-Schlesewsky, I., & Schlesewsky, M. (2013). Reconciling time, space and function: A new dorsal–ventral stream model of sentence comprehension. Brain and Language, 125(1), 60-76.
  4. Blank, I., Balewski, Z., Mahowald, K., & Fedorenko, E. (2016). Syntactic processing is distributed across the language system. [Article]. Neuroimage, 127, 307-323.

Further readings:

Fromkin, V. A. (1997). Some thoughts about the brain/mind/language interface. [Review]. Lingua, 100(1-4), 3-27. doi: 10.1016/s0024-3841(93)00028-7

Open Peer Commentary to Grodzinsky, Y. (2000). Behav Brain Sci, 23(1), 21-71.

Crosson, B., McGregor, K., Gopinath, K. S., Conway, T. W., Benjamin, M., Chang, Y. L., . . . White, K. D. (2007). Functional MRI of language in aphasia: a review of the literature and the methodological challenges. Neuropsychol Rev, 17(2), 157-177. doi: 10.1007/s11065-007-9024-z

Lieberman, P. (2007). The evolution of human speech - Its anatomical and neural bases. [Review]. Current Anthropology, 48(1), 39-66. doi: 10.1086/509092

Price, C. J. (2012). A review and synthesis of the first 20 years of PET and fMRI studies of heard speech, spoken language and reading. Neuroimage, 62(2), 816-847. doi: 10.1016/j.neuroimage.2012.04.062

Friederici, A. D. (2017). Evolution of the neural language network. Psychon Bull Rev, 24(1), 41-47. doi: 10.3758/s13423-016-1090-x